资源类型

期刊论文 471

会议视频 23

年份

2024 1

2023 62

2022 51

2021 53

2020 37

2019 29

2018 18

2017 10

2016 23

2015 16

2014 15

2013 14

2012 16

2011 20

2010 14

2009 15

2008 22

2007 27

2006 13

2005 4

展开 ︾

关键词

机理 9

医学 3

机制 3

2021全球工程前沿 2

DX桩 2

Maradbcm算法 2

作用机制 2

动力学 2

医学教育 2

原子力显微镜 2

双库协同机制 2

工程前沿 2

无氢渗碳 2

木质素 2

环境 2

绿色化工 2

能源 2

2022全球工程前沿 1

21世纪海上丝绸之路 1

展开 ︾

检索范围：

排序： 展示方式：

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

《医学前沿（英文）》 2023年 第17卷 第1期   页码 18-42 doi: 10.1007/s11684-022-0976-4

摘要： With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

关键词： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint inhibitors    

HTML PDF 收藏

Solvent-resistant porous membranes using poly(ether−ether ketone): preparation and application

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1536-1559 doi: 10.1007/s11705-022-2221-8

摘要： Poly(ether−ether ketone) (PEEK) is a linear aromatic macromolecule, which can form semi-crystalline aggregative status, allowing PEEK materials to have strong environment tolerance and excellent physicochemical properties. PEEK materials have become a promising alternative to fabricate particular membranes used in extreme conditions. In the past few decades, many researches and evolutions have emerged in membrane fabrication with PEEK materials and its applications for treating organic solvents and their mixtures; however, there are little systematic and comprehensive literature to summarize fabrication approaches, compile applications, and elaborate PEEK property-structure relationship. In this review, the main approaches to fabricate PEEK-based membranes are illustrated concretely, including conventional thermal-induced and non-solvent-induced phase separation, and novel chemical-induced crystallization; the representative applications in ultrafiltration, nanofiltration and membrane contactor containing organic solvents are demonstrated systematically. Meanwhile, the mechanism to tune PEEK solubility in solvents, which can be achieved by altering monomers in synthesis processes or changing membrane preparation routes, is deeply analyzed. Moreover, the existing problems and the future prospects are also discussed. This review provides positive guidance for designing and fabricating membranes using PEEK and its derivative materials for task-specific applications in harsh conditions.

关键词： PEEK     phase inversion     solvent-resistant membrane     nanofiltration     membrane contactor    

HTML PDF 收藏

Identification of resistant pharmaceuticals in ozonation using QSAR modeling and their fate in electro-peroxone

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1394-6

摘要：

• Effect of converting ozonation to E-peroxone was studied on pharmaceutical removal.

关键词： Ozone     Electro-peroxone     Wastewater     Quantitative structure activity relationship     Advanced oxidation processes    

HTML PDF 收藏

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

《医学前沿（英文）》 2022年 第16卷 第3期   页码 467-482 doi: 10.1007/s11684-021-0869-y

摘要： Cabozantinib, mainly targeting cMet and vascular endothelial growth factor receptor 2, is the second-line treatment for patients with advanced hepatocellular carcinoma (HCC). However, the lower response rate and resistance limit its enduring clinical benefit. In this study, we found that cMet-low HCC cells showed primary resistance to cMet inhibitors, and the combination of cabozantinib and mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells. Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest. Meanwhile, rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition. These effects were further validated in xenograft models. In conclusion, our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC.

关键词： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

HTML PDF 收藏

Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst

Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 88-94 doi: 10.1007/s11705-013-1301-1

摘要： The effect of adding Co, Ni or La on the methanation activity of a Mo-based sulfur-resistant catalyst was investigated. As promoters, Co, Ni and La all improved the methanation activity of a 15% MoO /Al O catalyst but to different extents. Similar improvements were also found when Co, Ni or La was added to a 15% MoO /25%-CeO -Al O catalyst. The promotion effects of Co and Ni were better than that of La. However, the catalytic methanation activity deteriorated the most with time for the Ni-promoted catalyst. The used catalysts were analyzed by nitrogen adsorption measurement, X-ray diffraction and X-ray photoelectron spectroscopy.

关键词： sulfur-resistant     methanation     promoter    

HTML PDF 收藏

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

《医学前沿（英文）》 2019年 第13卷 第1期   页码 24-31 doi: 10.1007/s11684-019-0679-7

摘要： Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpoint proteins, and molecular subtypes of cancers. Along with the Cancer Genome Project, various open access databases, including The Cancer Genome Atlas and Gene Expression Omnibus, provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors. In this review, we introduced some methodologies on database selection, biomarker screening, current progress of immune checkpoint blockade in solid tumor treatment, possible mechanisms of drug resistance, strategies of overcoming resistance, and indications for immune checkpoint inhibitor therapy.

关键词： immune checkpoint blockade     sensitivity     resistance     data mining    

HTML PDF 收藏

Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

《环境科学与工程前沿（英文）》 2016年 第10卷 第3期   页码 522-530 doi: 10.1007/s11783-015-0779-9

摘要： Antibiotic resistance is a serious public health risk that may spread via potable and reclaimed water. Effective disinfection is important for inactivation of antibiotic-resistant bacteria and disruption of antibiotic resistance genes. Ampicillin is a widely prescribed antibiotic but its effectiveness is increasingly undermined by resistance. In this study, changes in ampicillin resistance for ( ) CGMCC 1.1595 were analyzed after exposure to different doses of ultraviolet (UV) or chlorine, and damage incurred by the plasmid encoding ampicillin resistance gene was assessed. We reported a greater stability in ampicillin-resistant CGMCC 1.1595 after UV irradiation or chlorination when compared with previously published data for other strains. UV irradiation and chlorination led to a shift in the mortality frequency distributions of ampicillin-resistant when subsequently exposed to ampicillin. The ampicillin hemi-inhibitory concentration (IC ) without disinfection was 3800 mg·L , and an increment was observed after UV irradiation or chlorination. The IC of ampicillin-resistant was 1.5-fold higher at a UV dose of 40 mJ·cm , and was 1.4-fold higher when exposed to 2.0 mg·L chlorine. These results indicate that UV irradiation and chlorination can potentially increase the risk of selection for strains with high ampicillin resistance. There was no evident damage to after 1–10 mg Cl ·L chlorination, while a UV dose of 80 mJ·cm yielded a damage ratio for of approximately 1.2-log. Therefore, high UV doses are required for effective disruption of antibiotic resistance genes in bacteria.

关键词： antibiotic resistance     Escherichia coli     ampicillin resistance gene     ultraviolet irradiation     chlorination    

HTML PDF 收藏

Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes

Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma

《环境科学与工程前沿（英文）》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1120-9

摘要：

Reviewed the change of ARGs and ARB in full-scale urban drinking water systems.

Conventional processes are more promising than BAC process in ARGs removal.

Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed.

Raise the need of future research on ARGs and ARB change in building plumbing systems.

关键词： Antibiotic resistant bacteria     Antibiotic resistance genes     Water source     Drinking water treatment plant     Drinking water distribution system     Urban drinking water system    

HTML PDF 收藏

Surface-tailoring chlorine resistant materials and strategies for polyamide thin film composite reverse

《化学科学与工程前沿（英文）》 2022年 第16卷 第5期   页码 564-591 doi: 10.1007/s11705-021-2109-z

摘要： Polyamide thin film composite membranes have dominated current reverse osmosis market on account of their excellent separation performances compared to the integrally skinned counterparts. Despite their very promising separation performance, chlorine-induced degradation resulted from the susceptibility of polyamide toward chlorine attack has been regarded as the Achilles’s heel of polyamide thin film composite. The free chlorine species present during chlorine treatment can impair membrane performance through chlorination and depolymerization of the polyamide selective layer. From material point of view, a chemically stable membrane is crucial for the sustainable application of membrane separation process as it warrants a longer membrane lifespan and reduces the cost involved in membrane replacement. Various strategies, particularly those involved membrane material optimization and surface modifications, have been established to address this issue. This review discusses membrane degradation by free chlorine attack and its correlation with the surface chemistry of polyamide. The advancement in the development of chlorine resistant polyamide thin film composite membranes is reviewed based on the state-of-the-art surface modifications and tailoring approaches which include the in situ and post-fabrication membrane modifications using a broad range of functional materials. The challenges and future directions in this field are also highlighted.

关键词： reverse osmosis     polyamide     thin film composite membranes     chlorine resistance     surface modification    

HTML PDF 收藏

Vehicle roll stability control with active roll-resistant electro-hydraulic suspension

Lijun XIAO, Ming WANG, Bangji ZHANG, Zhihua ZHONG

《机械工程前沿（英文）》 2020年 第15卷 第1期   页码 43-54 doi: 10.1007/s11465-019-0547-9

摘要： This study examines roll stability control for vehicles with an active roll-resistant electro-hydraulic suspension (RREHS) subsystem under steering maneuvers. First, we derive a vehicle model with four degrees of freedom and incorporates yaw and roll motions. Second, an optimal linear quadratic regulator controller is obtained in consideration of dynamic vehicle performance. Third, an RREHS subsystem with an electric servo-valve actuator is proposed, and the corresponding dynamic equations are obtained. Fourth, field experiments are conducted to validate the performance of the vehicle model under sine-wave and double-lane-change steering maneuvers. Finally, the effectiveness of the active RREHS is determined by examining vehicle responses under sine-wave and double-lane-change maneuvers. The enhancement in vehicle roll stability through the RREHS subsystem is also verified.

关键词： electro-hydraulic suspension     roll stability     LQR     experiment    

HTML PDF 收藏

Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1502-7

摘要：

• LDHs and MMOs was synthesized by ultrasound-assisted one-step co-precipitation.

关键词： Heavy metal adsorption     Magnetic hydrotalcite     ARBs removal     Cr(VI)-MMOs combined antibacterial activity    

HTML PDF 收藏

Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

《工程（英文）》 doi: 10.1016/j.eng.2023.05.022

摘要： Infections with multidrug-resistant (MRD) Gram-negative bacteria, such as MRD Escherichia coli (E. coli), remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies. This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages, consisting of an intelligent controlling center (a living macrophage, MΦ) and a Fenton reaction catalyst (Fe3O4@poly(lactic-co-glycolic acid) (PLGA) nanoparticles) for killing MDR E. coli without harming normal cells. The MΦ–Fe3O4@PLGA particles (i.e., the intelligent catalysis particles) exhibit selective biocatalysis activity toward MDR E. coli by producing H2O2 and lipid droplets (LDs). This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis. The H2O2 further reacts with Fe3O4@PLGA to form highly toxic hydroxyl radicals (•OH), while the LDs contain antimicrobial peptides and can target MDR E. coli. The highly toxic •OH and antimicrobial peptides are shown to combat with MDR E. coli, such that the antibacterial efficiency of the MΦ–Fe3O4@PLGA particles against MDR E. coli is 99.29% ± 0.31% in vitro. More importantly, after several passages, the intelligent catalysis function of the MΦ–Fe3O4@PLGA particles is well maintained. Hence, the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.

关键词： Multidrug-resistant Escherichia coli     Macrophage–Fe3O4@PLGA particles     Biomimetic intelligent catalysis    

HTML PDF 收藏

Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 182-188 doi: 10.1007/s11684-017-0529-4

摘要：

With the abuse of antimicrobial agents in developing countries, increasing number of carbapenem-resistant Enterobacteriaceae (CRE) attracted considerable public concern. A retrospective study was conducted based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drug resistance characteristics of CRE in southeast China. Bacterial species were identified. Antimicrobial susceptibility was examined by broth microdilution method or epsilometer test. Resistant β-lactamase genes were identified by polymerase chain reaction and sequencing. Genotypes were investigated by phylogenetic analysis. and were the most prevalent types of species, with occurrence in 71.9% and 21.9% of the strains, respectively. All strains exhibited high resistance (>70%) against β-lactam antibiotics, ciprofloxacin, trimethoprim–sulfamethoxazole, and nitrofurantoin but exhibited low resistance against tigecycline (0.8%) and minocycline (8.3%). A total of 123 strains harbored more than two kinds of β-lactamase genes. , , , and were the predominant genotypes, with detection rates of 60.3%, 61.6%, 43.4%, and 16.5%, respectively, and were highly identical with reference sequences in different countries, indicating potential horizontal dissemination. IMP-4 was the most frequent class B metallo-lactamases in this study. In conclusion, continuous surveillance and effective prevention should be emphasized to reduce spread of CRE.

关键词： Enterobacteriaceae     carbapenem     β-lactamase genes     phylogenetic analysis    

HTML PDF 收藏

Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1333-y

摘要：

• Staff members were not colonised with MRSA.

关键词： Antibiotic resistance     Airborne MRSA     Bioaerosols     Healthcare-associated infections     Healthcare worker     Occupational health    

HTML PDF 收藏

深海装备耐压结构用钛合金材料应用研究

蒋鹏,王启,张斌斌,王洋

《中国工程科学》 2019年 第21卷 第6期   页码 95-101 doi: 10.15302/J-SSCAE-2019.06.018

摘要：

本文概述了国内外钛合金深海装备的发展现状，针对深海服役环境特点对耐压结构用钛合金材料的性能要求进行了分析，介绍了典型装备耐压结构钛合金材料研究应用中出现的应力腐蚀和蠕变等技术问题，提出需要针对钛合金材料长期服役时存在的组织演变和性能衰减、冲击环境下的动态响应等基础科学问题开展研究，重点梳理工程应用中的大规格材料、应用评价和高效建造等关键技术。文章建议针对深海领域钛合金装备的迫切需求，进一步加大钛合金材料基础研究和工程化应用力度，推动创新应用，践行海洋强国战略。

关键词： 深海装备     耐压结构     钛合金     关键技术    

HTML PDF 收藏

标题 作者 时间 类型 操作

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

期刊论文

Solvent-resistant porous membranes using poly(ether−ether ketone): preparation and application

期刊论文

Identification of resistant pharmaceuticals in ozonation using QSAR modeling and their fate in electro-peroxone

期刊论文

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

期刊论文

Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst

Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN

期刊论文

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

期刊论文

Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

期刊论文

Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes

Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma

期刊论文

Surface-tailoring chlorine resistant materials and strategies for polyamide thin film composite reverse

期刊论文

Vehicle roll stability control with active roll-resistant electro-hydraulic suspension

Lijun XIAO, Ming WANG, Bangji ZHANG, Zhihua ZHONG

期刊论文

Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal

期刊论文

Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant

Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,

期刊论文

Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou

null

期刊论文

Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

期刊论文

深海装备耐压结构用钛合金材料应用研究

蒋鹏,王启,张斌斌,王洋

期刊论文